Your numbers at this stage are very strong. The other one was smaller. For these reasons, it is very important to make individualized follow-up plans according to different serum -hCG intervals. The thresholds predicting clinical pregnancy and live births in these studies were higher than those in our study, which can be explained by the fact than only patients with a low -hCG were included in our research. An HCG value of 76 IU/l emerged as the most suitable cut-off point to predict viable pregnancy. An increase of at least 35% in 48 hours in early pregnancy is still considered normal. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Second, the study population in our research included patients with low serum levels of -hCG, whose transferred embryos may be less potent than those from patients having normal -hCG levels. Find advice, support and good company (and some stuff just for fun). Among patients with -hCG levels of 51100 mIU/ml, it was found that 55.8% were early miscarriages, 25.0% were biochemical pregnancies, and only 7.7% were live births. If the level was less than 300, the ongoing multiple pregnancy rate was 9% (5/57). Yet, they tend to decrease after the three month mark. I didn't know the gestational age for frozen embryo transfers were from the day of embryo transfer. I'm 40 years . Also in our present study, the live birth rate was 4.5% when the serum -hCG level was <100 mIU/ml at 14days after blastocyst transfer (Table 2), which is comparable to that of those observations found for day 3 embryo transfer [12]. The detection range lied between 1.2 and 225,000 mIU/ml. Cells from the placenta grow deep into the lining of the uterus, establishing a rich blood supply. Our previous study investigated the likelihood of live births with serum levels of -hCG <100 mIU/ml 14days after day 3 embryo transfer, which showed that the live birth rate was only 4.3%. The burse said numbers dont provide that info, onlu u/s.so now we just waiting. Thanks for the information. Beta hCG levels are increasing as you have witnessed yourself after the 4th of June. 2018 Jan;88(1):77-87. doi: 10.1111/cen.13481. There were no statistical differences between the groups in terms of the number of embryos transferred, the protocols of endometrial preparation, days of embryo transfer and endometrial thickness. This retrospective study included patients that had received a frozen blastocyst transfer in the Department of Reproductive Medicine of the Third Affiliated Hospital, Guangzhou Medical University (Guangzhou, China), between January 2014 and October 2019. A risk of a heterotopic pregnancy (one embryo develops in the uterus, while the other develops in the fallopian tube) is about 1%. Best of luck to you and congratulations! hCG levels chart in weeks from DPO (days past ovulation): 1 week DPO: 5 - 50 mIU/ml 2 weeks DPO: 5 - 426 mIU/ml 3 weeks DPO: 18 - 7,340 mIU/ml 4 weeks DPO: 1,080 - 56,500 mIU/ml 5 - 6 weeks DPO: 7, 650 - 229,000 mIU/ml 7 - 10 weeks DPO: 25,700 - 288,000 mIU/ml 11 - 14 weeks DPO: 13,300 - 254,000 mIU/ml 15 - 22 weeks DPO: 4,060 - 165,400 mIU/ml Not sure this information really helps you out as I know everyone is different. The study by Stone et al., showed that the doubling times of serum -hCG (-t2) increased from 1.6days on day 12, to a doubling time 3days on day 24 after embryo transfer [11], suggesting that -hCG doubled more quickly in early pregnancy. Predictive value of initial serum human chorionic gonadotropin levels for pregnancies after single fresh and frozen blastocyst transfer. In case you don't get a ton of answers here, you might get more there. Reprod BioMed Online. CONCLUSIONS: A single HCG reading on day 12 after embryo transfer helps to plan the subsequent follow-up. Prediction of patients that have had an hCG test other than 14days should be calculated according to the hCG doubling time of 48h, which limits its wider application. They have given me more hcg injections though "to sustain the pregnancy" and another scan in one week. In two recent studies of Yarali et al and lvarez et al,13 14 25 mg subcutaneous progesterone was added if progesterone level 1 day before embryo transfer was below the cut-off. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Is it a good level? A beta hCG level of over 100 is generally considered a good, positive result. Don't stress! The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not the user has consented to the use of Cookies. Im officially six weeks and 2 days. Serum hCG-beta levels of postovulatory day 12 and 14 with the sequential application of hCG-beta fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle. I guess 5 weeks is for the natural conception. The threshold for live births was 1.9 with an AUC of 0.808 (95% CI: 0.7240.891), a sensitivity of 88.5%, and a specificity of 64.5% (Fig. The transferred embryos were divided into two groups - early (cultivation 48 and 72 hrs) and prolonged cultivation (PC 96 and 120 hrs). In the present study, pregnancy outcomes of patients whose serum -hCG levels were < 300 mIU/ml 14 days after blastocyst transfer were investigated. Department of Obstetrics and Gynecology, Center for Reproductive Medicine/Department of Fetal Medicine and Prenatal Diagnosis/BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Key Laboratory of Reproductive Medicine of Guangdong Province, No. The threshold for live births was 108.6 mIU/ml with an AUC of 0.649 (95% CI: 0.0.5830.715), a sensitivity of 93.1%, and a specificity of 37.0% (Fig. A normal HCG level will roughly double every 48 to 72 hours, up to 6,000 mIU/ml. The author confirms that the work described has not been published before; that its publication has been approved by all co-authors; that its publication has been approved (tacitly or explicitly) by the responsible authorities at the institution where the work is carried out. Also, the egg retrieval procedure and the later embryo transfer can cause slight cramping in the days immediately after. Oron G, Shavit T, Esh-Broder E, Weon-Young S, Tulandi T, Holzer H. Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer. I was 38 when my twins were born and my MFM suggested that I do all non-invasive screenings plus an early anatomy scan at 16 weeks and then if anything came back abnormal we could elect to do an amnio as I was worried about doing the CVS (though I had assumed I would do it before I got pregnant). In sum, 164 patients had another serum -hCG test at 224days (mean: 6.75days) after the initial measurement, among which, 133 had increased -hCG levels and 31 had decreased values. Since it is detected in maternal serum as soon as 68days after fertilization, -hCG is widely used in the clinic as a marker of pregnancy. The rates of ongoing pregnancy were comparable between the progesterone supplementation group and the control group whose progesterone level was above the cut-off. Fertil Steril. I "pray" that both my little babies do well. Here are my results9dpt = 238, 10dpt = 557, 12dpt = 1473. 2007;22:10739. Poikkeus P, Gissler M, Unkila-Kallio L, Hyden-Granskog C, Tiitinen A. Obstetric and neonatal outcome after single embryo transfer. Craciunas L, Tsampras N, Coomarasamy A, Raine-Fenning N. Cochrane Database Syst Rev. Home Forums Infertility & Fertility Treatments Post Embryo Transfer Signs & Symptoms. In normal conception, -hCG levels are doubled every 48h, and consequently, this increased pattern is applied to discriminate normal pregnancy from a state of pathological pregnancy [1]. My HCG 13 days after my 5 day embryo transfer was over 1,300 and my 16 day post-transfer test showed over 3,500. And finally, no vanishing twin syndrome occurred in the setting of a twin pregnancy, with the notable exception of 14 total miscarriages. . Objective: Research on hCG Levels After IVF The effects of low-dose human chorionic gonadotropin combined with human menopausal gonadotropin protocol on women with hypogonadotropic hypogonadism undergoing ovarian stimulation for in vitro fertilization. Three protocols were available for endometrial preparation: 1) the natural cycle, 2) artificial cycle and 3) ovarian stimulation cycle. My next was 1430. Careers. However, the current study contained two disadvantages. I have transferred two frozen embryos on May 22nd and my first beta on May 31st was 28. 2022 Jan 17;26(1):62-67. doi: 10.5935/1518-0557.20210054. Oral estrogen (Estradiol Valerate, Bayer, Germany) at 3mg given twice daily, was started at 24days of the cycle and continued for at least 7days. When to Call Your Doctor Journal of Ovarian Research lol congrats :) hope you have a smooth pregnant and please update is either way :). Disclaimer. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. However, the serum -hCG levels of patients with live births (median: 196 mIU/ml) was significantly higher than that of patients with non-live births (median: 140 mIU/ml, P=0.0001; Table3). The HCG hormone level in the blood doubles every 48-72 h. If the HCG level doubles well, this indicates that the cells of the embryo are dividing well . It reaches its peak by 8-11 weeks of pregnancy and levels off. Based on these factors and a few others, her IVF success rate is 33.1% using donor eggs. Moreover, the timing of the hCG test in each center was highly variable. In an IVF procedure, a pregnancy test is done after two weeks to check the results. When is your ultrasound? Yes, those levels are good. Live birth indicated a pregnancy that continued after 28weeks of gestation with a live fetus evident. This is all very nerve racking. Press J to jump to the feed. The .gov means its official. HYL analyzed the data. Federal government websites often end in .gov or .mil. Objective: To determine the predictive value of serum hCG concentrations measured on the twelfth day after embryo transfer (D12) . I had it done at Cedar Sinai with Dr. Williams, who has done about 27,000 CVS procedures and has had good results compared to other clinics. Clinical pregnancy was defined as an intrauterine/extrauterine gestational sac that was detected by ultrasound with positive serum -hCG levels. You will probably get a lot of responses about checking the posts at the top of the page because they remind people that hormone levels are not an indication of a pregnancy with multiples. Our study showed that pregnancy outcomes of the patients with initially low serum -hCG levels were poor, with only 18.6% of live births. Hi! Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I think I will do CVS but was looking into cell free fetal DNA testing, which is the newest non-invasive screening test. Thank you for your response! Symptoms after embryo transfer during IVF treatment: from personal experience. My first pregnancy first hcg was 13 days after transfer and i had 2300 level. The authors declare that they have no competing interests. \). At my age, I definitely need to screen for abnormalities. So that means that by 14dp5dt, your hcg levels were probably very close to mine. Papageorgiou TC, Leondires MP, Miller BT, Chang AS, Armstrong AB, Scott LA, et al. Shamonki et al., confirmed that declining serum -hCG levels almost always led to a failed live birth, although they reported 3 cases of live birth with declined serum -hCG levels in a cohort of 6021 patients [10]. My nurse told me today that she made an error in my gestational age calculation (I knew it!) 2005-2023Everyday Health, Inc., a Ziff Davis company. Used to limit the percentage of requests. Design: My doctor has no idea what it could have been. And freq urination becoz i drank lots of water. Once I hear a heartbeat on Tue (crossing my fingers), I will do lots of research on this but what many woman are doing on this board sounds reasonable. ET; IVF; IVF ET. and transmitted securely. 2011 Dec;96(6):1362-6. doi: 10.1016/j.fertnstert.2011.09.042. Although prior work has attempted to predict pregnancy outcomes by assaying serum -hCG levels after blastocyst transfer, no study has focused on pregnancy outcomes in those with initially low serum -hCG levels. But a blood test can detect it earlier. Roughly. Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle. 1988 Jul;50(1):89-94 First, we only analyzed patients with low serum -hCG levels instead of investigating all pregnant patients, which will be helpful in developing appropriate suggestions of follow-up for this group of patients. Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction. Anyone else who has /had similar experience? Serum immunoactive inhibin levels in early pregnancy after in vitro fertilization and embryo transfer. My hCG is 575 (again, this is 10 days post embryo transfer). The site is secure. I was told by my clinic that the doubling time is more significant than the numbers. Luteal phase support was continued to week 10 when -hCG tests were positive. There may be suspicion with high numbers but just as many have normal range or high and not twins so will definitely need to wait for your ultrasound. If its doubling, then it means that everything is going as expected. Below 1,200 mIU/ml, hCG usually doubles every 48-72 hours, but 35%+ is still normal. I undergone with ivf on 26 August and on 9 September I did beta hcg test it was 44.34 again same day I did beta hcg it was 51.80. First HCG level after 14 days of transfer is 964. For vitrification, the blastocysts were equilibrated in an EquilibrationSolution for 2min and then transferred to a VitrificationSolution, wherein the embryos would remain for 4560s at 37C. 2003;80:135963. The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request. We use data about you for a number of purposes explained in the links below. Haiying Liu. The sensitivity of the assay was 1.2 mIU/ml, with an intra-assay coefficient of variation of 7%. Then I didn't even get anymore blood work. My girls are 20 months now. Congratulations on your pregnancy. statement and I truly understand as an older mom the emotions! Zhang X, Barnes R, Confino E, Milad M, Puscheck E, Kazer RR. For the stimulation cycle, 37.575IU of human menopausal gonadotropin (HMG) was administered for 24days of the cycle. HCG0 was defined as serum -hCG concentrations that were measured 14days after embryo transfer; HCG1 was defined as serum -hCG levels in the second test, and the term days represented the interval between the two -hCG tests. The threshold for live births was 108.6 mIU/ml with an AUC of 0.649, a sensitivity of 93.1% and a specificity of 37.0%. Normally, you do your first pregnancy test (HCG blood test) 14 days after embryo transfer.