First-in-human phase 1 study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody, in patients with HER2-positive advanced solid tumors. Swanson et al. Fuchs CS, et al. However, neither ramucirumab nor bevacizumab brought extra survival benefits when added to platinum or fluoropyrimidine chemotherapy in GC patients in the first-line settings [147, 148]. RC48 was well tolerated and showed promising antitumor activity in patients with HER2-positive advanced GC in a phase I trial [136]. A number of authors tend to the stage or simultaneous treatment with endoluminal aortic prosthetics, especially in patients with severe concomitant diseases, explaining this as a minimal risk of infection of the prosthesis [9]. Triulzi T, et al. Since Claudin 18.2 is also expressed on the normal gastric mucosal epithelial surface, the risk of adverse reactions and whether ADC drugs may aggravate normal mucosal damage should also be a concern. Google Scholar. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Lancet Gastroenterol Hepatol. Xu R-H, et al. J Clin Oncol. Another key strategy is combining ICI and other therapies, such as other ICI, targeted therapies, other immune-modulating agents, chemotherapy (as discussed above), and radiotherapy [191]. Xie T, et al. FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target? The trial showed a 2-month improvement in PFS, and the OS was not reached (NR) in the experimental arm (bemarituzumab+mFOLFOX6). According to a phase I study, ZW25 was well tolerated with durable response in heavily pretreated GEA patients (including prior HER2-targeted therapy) [86]. Wang F, et al. Addition of docetaxel to oral fluoropyrimidine improves efficacy in patients with stage III gastric cancer: interim analysis of JACCRO GC-07, a randomized controlled trial. Kwak EL, et al. In the cardiac region, a voluminous neoplasm was detected, dense, bleeding during a biopsy and spreading to the cardiac part of the esophagus. Estimated numbers of new cancer cases and deaths in 2022 (In 2022, there will be an estimated 1.9 million new cancer cases diagnosed and 609,360 cancer deaths in the United States.) Nat. Nab-paclitaxel versus solvent-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE): an open-label, randomised, non-inferiority, phase 3 trial. 1998;85:118590. HER2-targeted therapy suppresses downstream signaling pathways by blocking the binding of HER2 receptors and ligands, which inhibits the migration and proliferation of tumor cells and leads to apoptosis. Most GC patients are not susceptible to immune checkpoint inhibitor monotherapies. Further research aimed at prospectively collecting ctDNA is needed to confirm these findings. Secondary pure red cell aplasia (PRCA) is a rare but recognized immune related adverse event. Shitara K, et al. 2023 May 12;12(5):710. doi: 10.3390/biology12050710. 2023;41(2):25565. Hecht JR, et al. Lu L, et al. Gambardella V, et al. Morris HL, Da Silva AF. The anti-MET monoclonal antibody, onartuzumab, has been studied in a phase III trial of onartuzumab plus mFOLFOX6 vs placebo plus mFOLFOX6 in patients with metastatic HER2-negative G/GEJ cancers. 2. The neoplasm extended to the esophagus up to 1720mm (invasion?). Lancet Oncol. J Clin Oncol. Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer. More recently, the phase II/III MAHOGANY trial has reported the efficacy of margetuximab plus anti-PD-1 antibody retifanlimab (Cohort A) for the first-line treatment of patients with G/GEJ adenocarcinoma, with an ORR and a DCR of 53% and 73% [123]. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. J Clin Oncol. Preview abstract. The neoplasm extended to the esophagus up to 1720mm (pT3N3aM0 R0 stage IIIB TNM 8). 2018;19(11):143748. CAS Van Cutsem E, et al. Immune signatures following single dose trastuzumab predict pathologic response to preoperativetrastuzumab and chemotherapy in HER2-positive early breast cancer. https://doi.org/10.1186/s13045-023-01451-3, DOI: https://doi.org/10.1186/s13045-023-01451-3. It is hypothesized that a high TMB status results in the high expression of neoantigens, which are immunogenic and can induce the response of the immune system and potentially increase the efficacy of ICI treatment. Cancer Discov. A 56-year-old male patient underwent treatment for complaints of pain and discomfort in the epigastric region, general weakness and difficulty in passing food through the esophagus. Seo S, et al. Upon malignant transformation, CLDN18.2 expression can be retained in various tumor tissues, including G/GEJ cancer and especially diffuse-type GC [156]. Although emerging innovative drugs have made remarkable progress in GC treatments, extensive clinical explorations are needed to advance precision medicine. Supporters of EVISA includes: Literature / Source Database: Cancer treatment reports Description a medical journal published by the U.S. Department of Health and Human Services Status Through this selection of commissioned and primary research publications, we aim to underscore how much cancer therapy has advanced over the past several decades, which goals need to be prioritized, and the challenges that should be overcome to continue improving quality of life and outcomes for patients with cancer. Lee HJ, et al. Recently, many novel immune checkpoint modulators have been widely investigated, including LAG-3, VISTA, TIM-3, TIGIT, CD38, CD39, and CD73[190]. Yue S, et al. With the burgeoning use of ICIs, the association of secondary PRCA with an underlying lymphoproliferative disorder is often overlooked. CA Cancer J Clin. Surgical strategy for abdominal aortic aneurysm with concurrent symptomatic malignancy. Reports in Cancer and Treatment - Google Scholar Article CLDN18.2-specific CAR Tcells achieved partial or complete tumor regression in CLDN18.2-positive PDX models [164]. Other trials, such as phase III 2L DESTINY-Gastric04 and phase III 1L DESTINY-Gastric03, are also in progress (NCT04379596, NCT04704934). 2023;41(4):81625. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Hence, it is reasonable that tumors with MSI-H/dMMR status may attract more immune cell infiltration and enhance the effect of immune checkpoint inhibitors. 2012;30(3):26873. Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma. Thus, traditional simultaneous operations for gastric cancer and aortic aneurysms are technically feasible. As the flagship journal of the American Cancer Society, CA: A Cancer Journal for Clinicians reaches a diverse group of oncology specialists, primary care clinicians, and other professionals who interact with cancer patients. 2014;15(11):122435. 2021;27(7):192331. Receptor tyrosine kinase (RTK) amplification was commonly detected in MET-amplified metastatic GC, with 40% to 50% of cases exhibiting co-amplification of either HER2 or EGFR. 2011;29(30):396876. 2023;34(3):31920. Key clinical trial recommendations for development included: 1) PRRT re-treatment; 2) PRRT and immunotherapy combinations; 3) PRRT and DNA damage repair inhibitor combinations; 4) Treatment for liver dominant disease; 5) Treatment for PRRT resistant disease; and 6) Dosimetry modified PRRT. Improving early detection, reducing recurrence and optimizing treatment strategies are the primary challenges and prospects for GC management. The first BCR-ABL1 tyrosine-kinase inhibitor was discovered through drug screens in 1992, and in 2001 it became the first-line therapy with long-term remission rates for BCR-ABLdriven chronic myeloid leukemia1; second-generation tyrosine-kinase inhibitors, rationally designed to circumvent acquired resistance, earned approval from the US Food and Drug Administration as frontline therapies only a decade later. Marabelle A, et al. 3C). Journal. The patient underwent laparotomy. Li S, et al. CA Cancer J Clin. Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcgamma receptor binding properties. 2021;41(11):117382. Cell Rep Med. J Clin Oncol. Onohara T, Orita H, Toyohara T, Sumimoto K, Wakasugi K, Matsusaka T, et al. Li J, et al. Arch Surg. Efficacy of pembrolizumab monotherapy for advanced gastric/gastroesophageal junction cancer with programmed death ligand 1 combined positive score >/=10. National Cancer Institute; 2021. Fruquintinib was approved in China by the NMPA in September 2018 and commercially launched in late November 2018 as a third-line treatment for patients with metastatic colorectal cancer. Claudin 18.2 (CLDN18.2), a component of intercellular junctions [155], is exclusively detected in gastric mucosa and absent from other healthy tissues. In compliance with generally accepted rules of aseptic and antiseptics, the risk of infection of the vascular prosthesis is minimized. It is a first-in-class afucosylated monoclonal antibody against the FGFR2b splice variant frequently overexpressed in FGFR2- amplified G/GEJ cancers. The risk of rupture of . Lancet. INTRODUCTION Types of Articles Prior Publication Submission Checklist BEFORE YOU BEGIN Ethics in publishing Studies in humans and animals Informed consent and patient details Declaration of competing interest Declaration of generative AI in scientific writing Submission declaration and verification Use of inclusive language 2021;14(1):20. Mol Cancer. Trastuzumab deruxtecan (T-DXd) is an antibodydrug conjugate (ADC) composed of an anti-HER2 antibody connected to a cytotoxic topoisomerase I inhibitor via a cleavable tetrapeptide-based linker [130]. Ajani JA, et al. https://doi.org/10.1038/s43018-021-00192-x. In our observation, the operation began with gastrectomy, since the removal of the stomach as a single unit with a large omentum allowed to free up a significant space in the abdominal cavity, thereby providing convenient access to the aneurysm of the infrarenal aorta and greater freedom of manipulation. Premenopausal, perimenopausal, or postmenopausal women or men (18 years of age in most regions; 20 years in Japan) with hormone receptor-positive, HER2-negative locally advanced (i.e . Al-Batran SE, et al. Ann Oncol. Jiang H, et al. Genetics and molecular pathogenesis of gastric adenocarcinoma. Kang YK, et al. J Clin Oncol. Over the past 10years, we have only managed to find a few descriptions of the simultaneous performance of gastrectomy for GC and aortic prosthetics for aneurysm, while in the vast majority of cases, the placement of an aortic stent graft has been carried out endovascularly [9, 10]. Ivan Ivashov. Repeated RC controlled disease activity for 6 years . Lancet Oncol. Cancer Discov. 2023 May 22;11:e15373. 2015;18(3):47684. Ann Oncol. 2016;34(13):144854. GenesisCare, a global provider of cancer-treatment services backed by private-equity firm KKR, has filed for bankruptcy with plans to look for a buyer for its U.S. business. Lancet Gastroenterol Hepatol. Zhang J, et al. PubMed A recent study reconstructed unreported KaplanMeier plots of PD-L1 CPS subgroups of three phase III trials (CheckMate-649, KEYNOTE-062, and KEYNOTE-590) and investigated the outcome of low CPS subgroup [87]. Thuss-Patience PC, et al. Lancet. 2020;11(1):525. More than one-half (53%) of survivors were diagnosed within the past 10 years, and two-thirds (67%) were aged 65 years or older. J Clin Oncol. 2012;23(1):2836. eCollection 2023. Apatinib is a small molecule VEGFR inhibitor with China Food and Drug Administration (CFDA) approval for the treatment of advanced or metastatic chemotherapy-refractory GC. 2016;22(19):461925. Zolbetuximab is a chimeric IgG1 monoclonal antibody that binds to CLDN18.2 and induces antibody-dependent and complement-dependent cytotoxicity [160]. Oncol.2021;39(3_suppl):218. A phase II study (NCT05190445) is ongoing to investigate the efficacy of PRS-343 in combination with ramucirumab and paclitaxel in patients who have already received treatment for HER2-high (IHC 3+ or IHC 2+ with HER2/neu gene amplification)G/GEJ adenocarcinoma and in combination with tucatinib in HER2-low(IHC 1+ or IHC 2+ without HER2/neu gene amplification) G/GEJ adenocarcinoma. Sasako M, et al. In the second-line REGARD trial, ramucirumab demonstrated significant improvement in patient OS and PFS versus best supportive care in metastatic GC [144]. Diseases of the cardiovascular system (CVS) are the leading causes of death in the population of developed and developing countries. Tan P, Yeoh KG. Lancet. Catenacci DVT, et al. Research & Reviews: Journal of Reports in Cancer and Treatment 5 (3) , 2021. Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Introduction The number of cancer survivors continues to grow in the United States, primarily as a result of the combined effects of a growing and aging population as well as increases in cancer survival due to advances in early detection and treatment. Kim ST, et al. J Clin Oncol. Provided by the Springer Nature SharedIt content-sharing initiative. Kulukian A, et al. J Clin Oncol. Prospective observation: clinical utility of plasma Epstein-Barr virus DNA load in EBV-associated gastric carcinoma patients. Please enable it to take advantage of the complete set of features! Zhao H, et al. The results showed that adding pembrolizumab to trastuzumab and chemotherapy could markedly increase the ORR (74.4% vs. 51.9%; the estimated difference between the two groups was 22.7%; 95%CI, 11.233.7%; P=0.00006). Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. However, the challenge of determining the optimal treatment strategy and the appropriate timing of molecular biomarker screening has yet to be resolved. Zolbetuximab + CAPOX in 1L claudin-18.2+ (CLDN18.2+)/HER2 locally advanced (LA) or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Primary phase 3 results from GLOW. J Clin Oncol. MET/HGF pathway activation is associated with tumor invasiveness and poor disease prognosis. Accepted manuscripts They can be cited using the author(s), article title, journal title, year of online publication, and DOI. To obtain Top 100 in Cancer. 2023 May 15;13:1169616. doi: 10.3389/fonc.2023.1169616. Unfortunately, both studies were terminated due to increased number of deaths in the rilotumumab group[180, 181]. Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics. Kang YK, et al. Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. Targeted therapies, including anti-HER2, anti-angiogenesis, and other biomarker-directed therapies, have demonstrated promising efficacy in treating GC, with significant benefits observed in biomarker-enriched patients (Table 3). 2013;8(3): e54014. 2021;24(4):91325. Rivera F, et al. Most of the patients in this trial did not receive prior antiangiogenic therapies since they were not standard treatments in China at that time, so clinical evidence is still lacking for the use of apatinib in patients who previously received ramucirumab. J Clin Oncol. The chapter 11 filing . We anticipate the discovery of more potential ADC drugs and expect a breakthrough in first-line treatment. Maron SB, et al. For example, patients with melanoma, which used to be considered a deadly disease, have much better prospects thanks to the breakthroughs in targeted and immune-based therapies. 2014;15(12):138996. The authors declare that they have no competing interests. Despite the fact that both diseases have a very high risk of developing fatal complications, such as bleeding or rupture of an aortic aneurysm, there is no single surgical tactic in the treatment of these patients [3]. CA Cancer J Clin. PubMed Central 2013;31(15_suppl):40214021. 2021. 2021;39(15_suppl): 4002. J Clin Oncol. Jin Y, et al. Rui-Hua Xu, Wen-Long Guan, and Ye He drafted the manuscript and prepared the figures. Cancer Reports is an international, peer-reviewed, open access journal publishing basic, translational, clinical and interdisciplinary research in cancer biology, diagnosis, treatment, outcome, supportive care, epidemiology and health disparities. Pertuzumab in combination with trastuzumab and chemotherapy for Chinese patients with HER2-positive metastatic gastric or gastroesophageal junction cancer: a subpopulation analysis of the JACOB trial. J Clin Oncol. Bar-Sagi, D., Knelson, E. H. & Sequist, L. V. Nat. The infra-renal section of the aorta was up to 7cm in diameter (Fig. In a previous study, we demonstrated an artificial intelligence (AI) diagnostic platform, GRAIDS, to detect upper gastrointestinal cancers using real-world endoscopic imaging data from six Chinese hospitals with varying experience in the endoscopic diagnosis of upper gastrointestinal cancer [185]. 3B). KKR-Backed Cancer-Treatment Provider GenesisCare Files for Bankruptcy Different types of FGFR targeting agents were explored or developed in GC, including multikinase inhibitors, pan-FGFR inhibitors, FGFR1-3 inhibitors, selective FGFR inhibitors and ADC. Rui-Hua Xu, Wen-Long Guan, and Ye He collected the related references and participated in the discussion.
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