Valeriana jatamansi is popularly recognized as "Indian Valerian" and belongs to Valerianaceae family. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds . The present studies were thus carried out to evaluate their total phenolic content and antioxidant activities and to identify and quantify the major phenolic constituents present in them. Ascorbic acid was used as the standard, and the total antioxidant capacity was expressed as equivalents of ascorbic acid. The roots and the rhizomes of N. jatamansi, as mentioned in Ayurveda, have been used in various herbal formulations including dietary supplements. The roots of Nardostachys jatamansi and Selinum vaginatum were collected from Milam region (Uttarakhand) and Rohtang (Himachal Pradesh), India, in the months of September and October 2008, respectively. Studies have shown the prevalence of insomnia in 10%30% of the population worldwide,[1] while in India, it is 33%. The rhizomes of this hairy, perennial, dwarf and herbaceous plant are used for therapeutic effect in ayurvedic and unani system of medicine. Side effects of treatment with benzodiazepines. The .gov means its official. All medicines are dispensed in compliance with the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945. Federal government websites often end in .gov or .mil. Inclusion in an NLM database does not imply endorsement of, or agreement with, Received 2012 Nov 8; Accepted 2013 Feb 7. The sesquiterpenes (jatamansic acid, jatamansone), lignans, and neolignans are reported to be present in the roots of this plant. Materials and methods: The sources of information used in the study are government reports, dissertations, books, research articles and databases like Science-Direct, SciFinder . [18] The procedure involves assigning scores on 0-3 point scale as per the average intensity of the phenomenon observed. 2004, USAID . Antioxidant activity of apple peels. Griffin CE, 3rd, Kaye AM, Bueno FR, Kaye AD. Lyle, N.; Bhattacharyya, D.; Sur, K.T; Munshi,S. These methanolic extracts were stored at 5C till further use. Rakhshandah H, Hosseini M. Potentiation of pentobarbital hypnosis by Rosa damascena in mice. In the present investigation, the antioxidant properties and phenolic content of two important indigenous drugs of India, Nardostachys jatamansi and Selinum vaginatum, used in neurological disorders like epilepsy, hysteria, syncope, convulsions, and mental weakness were studied. One hour after drug administration, the animals were individually exposed to an open field apparatus (square box of 96 cm 96 cm with a sidewall of 15 cm height having 36 squares). Standard control (diazepam) decreased horizontal activity and total freezing time significantly compared to both groups (P < 0.001); whereas vertical activity was also decreased compared to NC (P < 0.001) and test drug (P < 0.01) groups [Table 2 and Figure Figure1a1a--cc]. Purnima, Bhatt M, Kothiyal P. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb.Journal of Pharmacognosy and Phytochemistry 2015; 3(5): 102-106. Orient J Chem 2016;32(2). Effect of test drugs on gross behavior parameters in albino rats, **P<0.01 in comparison to normal control, Data: MeanSEM. D./IAEC/13/2013/03) following the guideline formulated by Committee for the Purpose of Control and Supervision of Experiments on Animals, India. Diabetic study was also confirmed by using STZ injection [27]. The authors are grateful to the Director of National Botanical Research Institute, Lucknow, for providing the research facilities to carry out this work. The prooxidant/antioxidant balance is not only modulated by seizures per se but also by antiepileptic drugs. Materials and methods: Pre-treatment with N. jatamansi extract significantly prevented and restored the antioxidant enzyme activity and lipid peroxides to near normal levels [16]. De novo transcriptome analysis of the critically endangered - Nature SEM: Standard error of mean, Effect of test drugs on Rotarod performance of albino mice. eCollection 2022. Centrally acting skeletal muscle relaxant activity was evaluated using Rotarod performance on Swiss albino mice. The neuro behavioral activities [spontaneous motor activity and motor coordination] were also decreased significantly in MCA occlusion group. Nardostachys jatamansi was tested for antimicrobial activity along with other 61 medicinal plants belonging to 33 different families against some microorganisms. Keywords: Nardostachys jatamansi, Nardostachys chinensis, Valerianaceae, chemical structure, biological importance. the contents by NLM or the National Institutes of Health. The activities of Na [+] K [+] ATPase and catalase were declined significantly by MCA occlusion. Hydro alcoholic root extract from Nardostachys jatamansi was investigated for its antioxidant and anticataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring behavioural, biochemical parameters and neurotransmitter levels. Anonymous. ; Chakravarti, K.K. PMC The data generated during the study were analyzed with one-way ANOVA followed by Tukeys post Further, pre-treatment of rats with phenytoin at a dose of 12.5, 25, 50 and 75 mg/kg in combination with 50 mg/kg of N. jatamansi root extract resulted in a significant increase in the protective index of phenytoin from 3.62 to 13.17. Jatamansi contains 1 to 2% of pale yellow volatile oil, Nardostachys jatamansi, a medicinally important herb of Nepalese origin, . ; Sethu kumar Kamath M.; The evaluation of the radioprotective effect of Triohala in the mice exposed to gama-radiation. Significant increase in hypo-activity, passivity, relaxation, and ataxia were observed in the standard control diazepam treated group in comparison to the normal control group [Table 1]. Sahu R, Dhongade HJ, Pandey A, Sahu P, Sahu V, Patel D, et al. The decoction of the drug is also used in neurological disorders, insomnia, and disorders of cardiovascular system. ; Balasaheb, D.S. Orient J Chem 2016;32(2), Sahu R, Dhongade H. J, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. Medicinal Properties of Nardostachys jatamansi (A Review). government site. The root of V. jatamansi is a source of effective antileishmanial agent . Pachymic acid enhances pentobarbital-induced sleeping behaviors via GABAA-ergic systems in mice. The In-vitro antioxidant activity of N. jatamansi was studied by measuring the free radical scavenging activity. Zinzius, J.; Jatamansin- a new therapeutic agent in venous stasis and related diseases. Nardostachys jatamansi DC. [15] Alkaloidal fraction from rhizome possesses hypotensive action.[16]. Nardostachys jatamansi DC is a small perennial, rhizomatous herb which grows in steep, moist, rocky, undisturbed grassy slopes of India, Nepal, China and Bhutan from 2300 m to 6000 m above sea level. diabetes, aging, heart problem, cancer and neurodegenerative disorders. The present study was carried out to evaluate the antidiabetic activity of Nardostachys jatamansi ethanolic rhizome extract in alloxan induced diabetic rats for 7 days. Bagchi, A.; Oshima, Y.; Hikino, H.; Neolignans and lignans of N. jatamansi roots. Kokate, C.K. Bose, B.C; Vijayvarngiya, R.; and Bhatnagar, J.N; Rucker, G.; Paknikar, S.K; Mayer, R.; Breitmaier, E.; Will, G. and Wiehl, L.; Revised structure and stereochemistry of jatamansic acid, Bagchi, A.; Oshima, Y.; Hikino, H.; Spirojatomol, A new skeletal sesquiterpenoid of, Bagchi, A.; Oshima, Y.; Hikino, H.; Jatamols A and B: sesquiterpenoids of. They were authenticated by Dr. A. K. S. Rawat, Head of Pharmacognosy & Ethnopharmacology Division, CSIR-NBRI, by comparison with authentic herbarium specimens and samples and deposited (Voucher specimen numbers 227331 and 227332) in the departmental herbal drug museum for future reference. (b) Number of rearing. Standard ascorbic acid was found to exhibit 83.19% activity at 5g/mL concentration. The dose reduction factor (DRF) of jatamansi extract was calculated by taking the ratio between LD50 of EBR with and without N. jatamansi extract treatment [35]. Introduction. In: Laurence DR, Bacharacha AL, editors. ; Ahmad, A.S.; Islam, F.; Protective effect of. An overview on the biological perspectives of Nardostachys Jatamansi The large lipid content of myelin sheaths and the high rate of brain oxidative metabolism coupled with the low antioxidant defenses make the brain highly vulnerable to free radical damage [5, 6]. Zheng YD, Ma LM, Lu JJ, Chai T, Naghavi MR, Ma JY, Sang CY, Yang JL. It is found from 2200m to 5000m asl. Data suggested that Jatamansi did not produce any adverse effect on the behavior of animals grossly which indicates its safety profile at a given dose. On pentobarbitone-induced sleeping time, the test drug-treated group showed a significant reduction in latency of onset of sleep (P < 0.01) and also extended the total duration of sleep in albino mice in comparison to the control group (P < 0.05). ; Throat, R.M. ; Maheswari, M.L. jatamansi DC.) Coumarins of the petroleum ether extract. They resemble each other in their external morphological characters and characteristic odour, so their roots are often confused with each other. A direct correlation was found to exist between the concentration of the extract used and the spectrophotometrically measured phosphomolybdenum complex (R Briefly, to a methanolic solution of DPPH (100mM, 2mL), 2.0mL of test sample dissolved in methanol was added at different concentrations (40200 g/mL). Habibur, R.; Muralidharan, P.; Comparative study of antidepressant activity of methanolic extract of N. Jatamansi DC Rhizome on normal and sleep deprived mice, Rasheed, A.S.; Venkataraman, S.; Jayaveera, K.N. potential sources of sesquiterpenes of common and lesser . Mori A, Noda Y, Packer L. The anticonvulsant zonisamide scavenges free radicals. 2022 Nov 29;13:1041321. doi: 10.3389/fpls.2022.1041321. Essential oils and the component jatamansone have shown such activities experimentally. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. minutes and filter it. 2022 Mar 7;27(5):1735. doi: 10.3390/molecules27051735. IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS) e-ISSN:2278-3008, p-ISSN:2319-7676. . [4] It is found at an altitude of 3,0005,000m (9,80016,400ft). The ethanolic extract at high dose (1400 mg/kg) exhibited significant antihyperglycemic activity than at low dose (500 mg/kg) in diabetic rats. Watzman N, Barry H, 3rd, Buckley JP, Kinnard WJ., Jr Semiautomatic system for timing rotarod performance. "IUCN Red List of Threatened Species: Nardostachys jatamansi", Original botanical description by David Don, https://en.wikipedia.org/w/index.php?title=Nardostachys_jatamansi&oldid=1153484762, IUCN Red List critically endangered species, Pages using eFloras template without author names, Taxonbars with multiple manual Wikidata items, Taxonbars with automatically added basionyms, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 6 May 2023, at 17:44. ; Jafri, M.A. It also shows marked tranquillizing activity, hypotensive, hypolipidemic, hepatoprotective, neuroprotective, anti-ischemic, antiarrhythmic and anticonvulsant activities.
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