2-10-2010;627(1-3):209-215. Hacker B, Medon PJ. Maturitas 2008;61(1-2):181-193. 2013 Jul;46:181-90. Eksp Klin Farmakol 1997;60:58-60. Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. Kimura, Y. and Sumiyoshi, M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. Zhong.Xi.Yi.Jie.He.Za Zhi. Signs of high blood pressure like very bad headaches, nervousness, problems breathing, or nosebleeds. 10-28-2010;132:193-199. Wilson, L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, Panax ginseng, Rhodiola rosea, Schisandra chinensis and Withania somnifera. 2020;14:322-333. Effects ofEleutherococcus senticosusCortex on Recovery from the Forced Swimming Test and Fatty Acid -Oxidation in the Liver and Skeletal Muscle of mice. Compounds in eleuthero have also been shown to prevent the formation of ulcers, including diabetic foot ulcers. Since more reliable information is necessary, talk with a healthcare provider if you're considering eleuthero for your child. Phytother Res 2005;19:167-169. Zhongguo Zhong Yao Za Zhi 1994;19:746-7, 764. 2011;72(8):689-699. doi: 10.1016%2Fj.phytochem.2011.02.012, Siberian Ginseng. Whole Powder: 1-4 grams per day for adults (healthy individuals should use the lower range, the higher range should be used by those with illness or in high-stress situations), Standardized Extract (with Eleutheroside E): 1.25g dose can be taken 1-3 times daily. & Maxim.) Chem Pharm Bull (Tokyo) 2007;55:1087-1089. The root of the plant is most often used medicinally and is available in supplement and tea form. Eleutherococcus Uses, Benefits & Side Effects - Drugs.com Classification for kingdom Plantae down to species Eleutherococcus senticosus. But according to the NLM, taking eleuthero for up to six weeks is typically safe for teenagers. This lets it work as a detox flush and overall immune booster. Eleuthero was frequently used in TCM (Traditional Chinese Medicine) for inflammatory diseases. Liang, Q., Yu, X., Qu, S., Xu, H., and Sui, D. Acanthopanax senticosides B ameliorates oxidative damage induced by hydrogen peroxide in cultured neonatal rat cardiomyocytes. New research shows that it helps to improve energy and physical stamina, as well as support the immune system. Some experts believe that this plant may have strong potential to be developed as an effective anticancer drug. We recommend using it in conjunction with other adaptogenic herbs like Rhodiola or Ashwagandha to improve their effectiveness in combating the effects of physical and mental stressors. There is evidence that eleuthero was first used as an herbal remedy in China some 2,000 years ago. Jung, C. H., Jung, H., Shin, Y. C., Park, J. H., Jun, C. Y., Kim, H. M., Yim, H. S., Shin, M. G., Bae, H. S., Kim, S. H., and Ko, S. G. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. https://pubmed.ncbi.nlm.nih.gov/21793317/. [Effect of eleutherosides on ventricular late potential with coronary heart disease and myocarditis]. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Early intervention with Kan Jang to treat upper-respiratory tract infections: A randomized, quadruple-blind study. Bespalov, V. G., Aleksandrov, V. A., Iaremenko, K. V., Davydov, V. V., Lazareva, N. L., Limarenko, A. I., Slepian, L. I., Petrov, A. S., and Troian, D. N. [The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea]. Kupin, V. I., Polevaia, E. B., and Sorokin, A. M. [Immunomodulating action of an Eleuterococcus extract in oncologic patients]. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Effects of R. glutinosa and E. senticosus on postmenopausal osteoporosis. Eleutherococcus senticosus. Park, E. J., Nan, J. X., Zhao, Y. Investigating the power of music for dementia. Sumiyoshi, M., & Kimura, Y. Call 911 and get medical help immediately if you're having a severe allergic reaction or if any of your symptoms feel life-threatening. Donovan JL, DeVane CL, Chavin KD, et al. B., Lee, J. J., and Sohn, D. H. Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. Phytother.Res 2008;22:204-212. Vopr.Med Khim. Acta Pharmacol Sin. Phytomedicine 1999;6:217-23.. Winther K, Ranlov C, Rein E, et al. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Harkey MR, Henderson GL, Zhou L, et al. Eleuthero is a plant that has been traditionally used as an immune system booster and a general stimulant. Yim, S, Jeong JuCheol, and Jeong JiHoon. Huang, L., Zhao, H., Huang, B., Zheng, C., Peng, W., and Qin, L. Acanthopanax senticosus: review of botany, chemistry and pharmacology. Australian Journal of Medical Herbalism 2010;22:41-49. Its very important to buy eleuthero products from a reputable sources because quality is known to vary significantly. But similar to many medications and natural products, side effects and medication interactions are still possible. Int J Sport Nutr Exerc.Metab 2005;15:75-83. Discard after one year or as indicated on the packaging. Am J Clin Nutr 2001;73:1101-6. Huang, D. B., Ran, R. Z., and Yu, Z. F. [Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer]. J Ethnopharmacol. If you suspect you're experiencing life-threatening side effects, seek immediate medical attention. Kormosh, N., Laktionov, K., and Antoshechkina, M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. 1-7-2011;133:213-219. Siberian ginseng is an herb used in traditional Chinese medicine. Before taking eleuthero, involve a pharmacist or healthcare provider to help you safely achieve your health goals. Eleuthero Root Benefits And Uses Explained - Maple Holistics Schutgens FW, Neogi P, van Wijk EP, et al. Int J Clin Nutr. Pharmacopsychiatry. Eleuthero is a safe herb with promising abilities for increasing energy and stamina, as well as stress adaptation, and immune health. Memorial Sloan Kettering Cancer Center. Also known as Siberian ginseng, eleuthero is an herb with the scientific names Eleutherococcus senticosus or Acanthopanax senticosus. This article discusses what you should know about eleutheroits potential uses, side effects, and interactions. . It should be noted that in this study, the researchers were looking at arthritis-induced inflammation. So, these proteins will be less efficient at breaking down certain medicationslike warfarin. Plowman, S. A. K. Dustman H. Walicek C. Corless and G. Ehlers. In general, adaptogens like eleuthero are excellent at helping your body handle stress, whether itsphysical, chemical or biological. Eleuthero is often considered an. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. 1982;29:567-573. According to a scientific article entitled Deconstructing an adaptogen: Eleutherococcus senticosus, the dried roots and rhizomes of Eleutherococcus senticosus (Araliacaea) plant are used in various preparations, primarily for its adaptogenic properties. Increase of beta-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats. Zhongguo Zhong Yao Za Zhi 1994;19:683-5, 703. Always check with your doctor before taking a new herbal remedy, especially if you are pregnant, breastfeeding, taking medication or have an ongoing medical condition. Others dry the leaves and add them to a natural tea mixture. Sov.Med 1987;:114-116. It comes in supplements as powders, solid and liquid extracts, capsules, tablets, and as dried or cut root for tea. For this reason, people in this age group should take eleuthero with caution. A randomized, controlled, animal study published in the journal, Neural Regeneration Research, looks at the effects of eleutheroside B and E on learning and memory in experimentally aged rats. CMAJ 1996;155:293-5. Link. Provalova, N. V., Skurikhin, E. G., Pershina, O. V., Minakova, M. Y., Suslov, N. I., and Dygai, A. M. Possible mechanisms underlying the effect of natural preparations on erythropoiesis under conditions of conflict situation. What is the most common dosage form of eleuthero? Winston, David. Eleuthero root and rhizomes (underground stem) are the part of the plant that people use medicinally. Voprosy onkologii,32(7), 2126. Last medically reviewed on August 23, 2017. He also notes that long-term use of eleuthero makes one feel happy and vigorous and that it helps retard aging (Winston, 2019). Kuo, J., Chen, K. W., Cheng, I. S., Tsai, P. H., Lu, Y. J., & Lee, N. Y. Zhang, X. L., Ren, F., Huang, W., Ding, R. T., Zhou, Q. S., and Liu, X. W. Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus. Wagner, H., Proksch, A., Riess-Maurer, I., Vollmar, A., Odenthal, S., Stuppner, H., Jurcic, K., Le, Turdu M., and Heur, Y. H. [Immunostimulant action of polysaccharides (heteroglycans) from higher plants. Proponents of the Siberian version actually say that eleuthero may be even more adaptogenic! United States Department of Agriculture. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. Accessed December 2019. on elderly quality of life: a randomized clinical trial. 10-8-2007;114:38-43. Drozd, J., Sawicka, T., and Prosinska, J. Estimation of humoral activity of Eleutherococcus senticosus. Rhaume, K. Adapting to stress. 7 Surprising Benefits of Eleuthero - Dave Asprey The Herbal Alternatives for Menopause (HALT) Study: background and study design. Eschbach LF, Webster MJ, Boyd JC, et al. A 2013 study found that 480 mg per day of eleuthero significantly lowered fasting and post-meal blood sugar levels in subjects with type 2 diabetes. Med Sci Sports Exerc 1998;30 Suppl:S323. There are different sources of eleuthero. Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, http://www.sararegistry.gc.ca/document/default_e.cfm?documentID=1562, https://link.springer.com/article/10.1007/s11418-011-0509-y, http://journal.waocp.org/article_31161_a02bdd20336d9210237e3594ff7fdc60.pdf, http://www.sciencedirect.com/science/article/pii/S0271531716000531, http://www.sciencedirect.com/science/article/pii/S0378874110006732?via%3Dihub, https://www.ncbi.nlm.nih.gov/pubmed/21793317, http://www.mdpi.com/1420-3049/18/7/7998/html, http://www.naturalmedicinejournal.com/journal/2012-03/siberian-ginseng-review-literature, https://www.researchgate.net/publication/273269743_Myths_and_facts_in_herbal_medicines_Eleutherococcus_senticosus_Siberian_ginseng_and_its_contraindication_in_hypertensive_patients, https://www.ncbi.nlm.nih.gov/pubmed/27731802, Researchers investigate what causes psoriasis and how it spreads, Low-dose atropine eyedrops may delay onset of nearsightedness in children, Heart attack may speed up cognitive decline, study finds, Type 2 diabetes: 1 in 5 'healthy' people may have prediabetes metabolism, Cataract surgery: Medicare reimbursements differ between simple and complex operations, Two common iron supplements may cause cancer, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Eleuthero may, therefore, lessen the effects of estrogen withdrawal in women who are experiencing menopause. Herbs and Spices Eleuthero Top 10 Benefits of Eleuthero by John Staughton (BASc, BFA) last updated - February 03, 2020 Evidence Based The most important health benefits of eleuthero include its ability to relieve stress, increase cognitive function, boost the immune system, and reduce fatigue. Immunopharmacol.Immunotoxicol. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Am J Clin Nutr 2000;72:624S-36S.. Smeltzer KD, Gretebeck PJ. Chest pains. [Effect of Eleutherococcus on respiratory viral infectious morbidity in children in organized collectives]. In traditional and herbal medicines, eleuthero is used to treat dozens of different health conditions. Cicero AF, Derosa G, Brillante R, et al. Healthcare providers may want to monitor you closely and adjust your medications accordingly. National Center for Complementary and Integrative Health. Herbal products can react with certain medications, causing a negative reaction or decreasing the effect of the medication. Eleuthero has a scientific name of Eleutherococcus senticosus (E. senticosus). Arzneimittelforschung. As an adaptogenic herb, this makes sense, as adaptogens are noted to be safe for long-term use. Eleuthero has a scientific name of Eleutherococcus senticosus ( E. senticosus ). The botanical safety handbook [2nd edition]. 2 8-15-2007;113:183-187. You can find eleuthero supplements incapsule, tablet, tincture, solid extract, or powder form online or at your local health food store. Natural Health 2007;38:91-94. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. By the study's end, the herbal mixture group reported less pain and better knee function when compared to the placebo. These are early intuitions of its present status as an adaptogen. Vopr.Onkol. What's more, there were fewer signs of lymphocyte (a type of white blood cell) DNA damage. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Phytother Res 2004;18:47-53. It is sometimes used as an adaptogen. Newton, K. M., Reed, S. D., Grothaus, L., Ehrlich, K., Guiltinan, J., Ludman, E., and Lacroix, A. Huang, L. Z., Huang, B. K., Ye, Q., and Qin, L. P. Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus. J Ethnopharmacol. For this reason, eleuthero might interact with other medications that affect the immune system, including immunosuppressant drugs like Humira (adalimumab). Provino, R. The role of adaptogens in stress management. Thus, eleuthero would have been used in illnesses such as rheumatism. Pediatriia. The active constituents are thought to be a group of compounds known as eleutherosides. Newton, K. M., Reed, S. D., LaCroix, A. And these plant substances are likely responsible for how eleuthero works. The FDA outlines specific guidelines and regulations for the production, marketing, and sale of herbal supplements. Chen, C. Y. O, Ribaya-Mercado, J. Smalinskiene, A., Lesauskaite, V., Zitkevicius, V., Savickiene, N., Savickas, A., Ryselis, S., Sadauskiene, I., and Ivanov, L. Estimation of the combined effect of Eleutherococcus senticosus extract and cadmium on liver cells. Curr Clin Pharmacol. 2020 Jan 23;12. pii: E303. Zhang, Y. American Herbal Products Association's Botanical Safety Handbook. Eleuthero also acts as a stimulant, increasing nervous system function.