Platonov, A. E. et al. Sci. Scand. 3. npj Vaccines 2, 12 (2017). PLoS Pathog. 42, 4360 (2020). Rev. demonstrated that pattern recognition receptors (PRRs) expressed on innate cells recognize invariant molecular structures expressed by invading pathogens82. Allergy Clin. 7, 585 (2016). SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from It measures the scientific influence of the average article in a journal, it expresses how central to the global scientific discussion an average . Transl. Med. Systemic autoinflammatory diseases (AIDs) are characterized by recurrent acute inflammatory episodes secondary to a dysregulated inflammatory process that typically develops during childhood, with recurrent episodes of fever, rashes, and disease-specific patterns of organ inflammation. Cancer 8, 473480 (2008). Combinations with other components (immunomodulators, drugs, and cytokines) are also being explored to suppress antiviral immunity and enhance antitumoral cytotoxicity199. Rev. Sci. Currently, vaccines are among the factors that, together with hygiene, antibiotics and surgery, save the most lives181. 3, e26 (2007). J. Immune surveillance is the recognition and elimination of cancerous cells by lymphocytes, which act as sentinels that recognize transformed cells. The first virus approved for use in therapy was a recombinant oncolytic adenovirus named H101, which was licensed in 2005 by the China Food and Drug Administration (CFDA) for treating head and neck carcinoma in combination with chemotherapy191. Intravenous immunoglobulins are aimed at blocking inflammation and preventing secondary infections312. Nat. Davidson, S., Steiner, A., Harapas, C. R. & Masters, S. L. An update on autoinflammatory diseases: interferonopathies. A real challenge in the field of cellular immunotherapy is the acquisition of universal off-the-shelf cell therapies to replace those currently made to order in a very personalized manner. About The Journal of Immunology | The Journal of Immunology | American Regarding gut microbiota manipulation as a therapeutic approach, fecal microbiota transplantation is an effective therapy for recurrent Clostridium difficile infection332 and is now being investigated for other indications, such as inflammatory bowel disease and cancer. Immunity 48, 10911103 (2018). 12, 20252038 (2018). & Graca, L. T follicular regulatory cells in mice and men. Cytokine Growth Factor Rev. immunol. 129, 434440 (2012). If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website. Rodriguez . Moreover, the CAR includes all of the necessary elements for intracellular signaling and activation of helper and cytotoxic T lymphocytes. Nat. Blood 119, 26652674 (2012). Researchers are boosting trained immunity, a new concept related to the innate immune memory-like described for NK cells (expansion) and macrophages (epigenetic modifications). & de Jong, E. C. Dendritic cell science: more than 40 years of history. This work was financially supported by the Ministerio de Economa y Competitividad (BIO2017-84974-R), Xunta de Galicia Grupo Referencia Competitiva 2016 (ED431C 2016/041) and the European Union (European Regional Development Fund, Ref. Klein, N. P., Abu-Elyazeed, R., Cheuvart, B., Janssens, W. & Mesaros, N. Immunogenicity and safety following primary and booster vaccination with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus and Haemophilus influenzae type b vaccine: a randomized trial in the United States. 19, 599613 (2019). In addition, Th22 cells, which produce IL-22 and express the aryl hydrocarbon receptor (AHR)47,62, and Th9 cells, are characterized by the expression of IL-9 and the transcription factor PU.163. Abrahamsson, T. R. et al. To date, six gene products endowing infectious disease susceptibility have been validated in the literature: (1) hemoglobin subunit beta; (2) band 3-anion transport protein; (3) Duffy antigen/receptor, which is associated with Plasmodium spp. With respect to studies on human arthritis, Nistala et al.79 proposed that Th17 cells are recruited to the joint and converted to Th17/1 or Th1 cells in response to local IL-12 levels. De Jong, E., Suddason, T. & Lord, G. M. Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. II. This discovery opened the way to exploring the potential clinical applications of conventional antiserum-containing polyclonal antibodies from immunized animals/humans214. Cancer immunotherapy using CAR-T cells: from the research bench to the assembly line. Th1 cells are required to activate macrophages and cell-mediated immunity to kill intracellular pathogens42, whereas Th2 cells are important in facilitating eosinophils to fight against parasitic helminths and B cells for antibody production and antibody class-switching to generate IgA or IgE43. Rogers, L. M., Veeramani, S. & Weiner, G. J. Complement in monoclonal antibody therapy of cancer. This long journey has been possible due to the efforts of numerous researchers (throughout the centuries), who have contributed with their work, creativity, successes and failures to advance our knowledge of the immune system, cellular components, membrane markers, interactions, signaling pathways and many more aspects. The interferon family is the largest family of cytokines and is classified into three different types (I, II, and III). 192, 54515458 (2014). CAR T-cell therapy was initially designed for use against hematological cancers (leukemia and lymphomas), but many new opportunities have been opened for its use against solid tumors308, infectious diseases (such as HIV)309, allotransplantation, autoimmune diseases310 and severe allergies311. Immunol. Nat. Strateg. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. In particular, minor histocompatibility antigens, which are peptides derived from allelic variants of normal cellular proteins, presented by class I or II MHC antigens induce cellular immune responses in HLA-matched individuals who lack the same allelic variant150. Kalos, M. et al. Immunol. 53, 751759 (2014). Primary immunodeficiencies (PIDs) comprise a heterogeneous group of more than 400 genetic disorders that result in defects in the immune response152. Inquiry 56, 004695801989409 (2019). The process of aging alters the innate and adaptive immune systems. Res. Researchers started to design new recombinant IL-2 with some mutations to avoid the activation of Tregs267, with linking it to polyethylene glycol (PEG) to increase its half-life and efficacy268. J. Immunol. Drug Discov. Posch, W., Lass-Flrl, C. & Wilflingseder, D. Generation of human monocyte-derived dendritic cells from whole blood. Cancer Res. Maceiras, A. R., Fonseca, V. R., Agua-Doce, A. Charych, D. H. et al. Allergy Clin. The latter example is a fusion protein that combines the extracellular portion of human CTLA-4 and IgG1 Fc. The cells are expanded in the presence of cytokines in culture and are subsequently reinfused into the patient. Curr. Immunol. This lesser coverage enables pathogens to infect the most susceptible people, such as small children, elderly patients and those who cannot be vaccinated due to certain pathologies or because they are undergoing immunosuppression treatment. tTregs express the transcription factor Foxp3 and secrete IL10 and TGF-; pTregs, which are induced in the periphery from nave precursors, can also be subdivided into IL-10-induced Tregs [Tr1 cells] (which secrete large amounts of IL-10 and moderate levels of TGF), TH3 cells (which produce IL-10 and TGF-), and TGF-induced Tregs [iTregs], which may or may not express Foxp3. Jiang, X. R. et al. & Yokoyama, W. M. Memory-like responses of natural killer cells. The recall response persisted for more than four months after priming, and was adoptively transferred to nave mice100. Eissa, I. R. et al. Dunn, G. P., Old, L. J. Cancer 7, 36 (2019). Cancer Res. Ther. Th17 cells produce IL-17A, IL-17F, and IL-22 and express RORt60,61, and Tfh cells produce IL-4 and IL-21 and express the BCL6 transcription factor. Immunol. - Oncolytics 15, 234247 (2019). Exp. Immunol. Human NK cells: surface receptors, inhibitory checkpoints and translational applications. Nasal mucosal cells comprise CD8+ T cells, CD4+ T cells, myeloid cells, innate lymphoid cells, B cells, double-negative T cells, granulocytes, CD117+ cells, and plasma cell populations165. und fr. The epigenetic landscape is specific for a given cell; thus, EWAS requires careful selection of the relevant cell type for a given biomedical condition. & Fainboim, L. Human CD8+ HLA-DR+ regulatory T cells, similarly to classical CD4+ Foxp3+ cells, suppress immune responses via PD-1/PD-L1 axis. Romani, N. et al. & Wise-Draper, T. M. Oncolytic virotherapy for head and neck cancer: current research and future developments. Clin. Large variability in terms of remission and durable clinical benefits between patients is observed (for example, in the antitumoral responses by antibodies directed to the checkpoint inhibitors). 7. Immunol. Primary immunodeficiency diseases in highly consanguineous populations from Middle East and North Africa: epidemiology, diagnosis, and care. Today 17, 138146 (1996). Impact Factor of Advances in Immunology, impact factor 2021 | Journal Decker, W. K. & Safdar, A. Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coleys legacy revisited. When it binds to its ligand on tumor cells, PD1 inhibits tumor cell apoptosis, causes peripheral effector T-cell exhaustion, and promotes the conversion of effector T cells into regulatory T cells172,174. Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A. Biol. Pluviano, S., Watt, C. & Della Sala, S. Misinformation lingers in memory: failure of three pro-vaccination strategies. MAbs 10, 183203 (2018). tremendous role of International Union of Immunological Societies (IUIS) and its Expert Committee updating categorization of IEI approximately every 2 years. J. Intern. Another cytokine described later, IL-15, showed similarities to IL-2 in many respects269, and it had some unique advantages, such as the capacity to activate NK and cytotoxic T cells (Tc) but not Tregs. 34, 130136 (2015). Some lymphocytes escape control due to polymorphisms in several genes that affect the routes of lymphocyte activation. PubMed Central Ned. Nat. The gut microbiota influences blood-brain barrier permeability in mice. Investig. Immunol. B., Felices, M., Verneris, M. R. & Miller, J. S. Natural killer cell adoptive transfer therapy. Cell Rep. 18, 17611773 (2017). Nat. In terms of innate immunity, aging results in a decreased number of circulating monocytes and dendritic cells, reduced phagocytic properties of macrophages and neutrophils, and impaired antigen presentation by dendritic cells179. J. Clin. Kaplon, H. & Reichert, J. M. Antibodies to watch in 2019. Advances in Immunology Impact Factor & Key Scientometrics Advances in Immunology Overview Impact Factor 3.543 H Index 110 Impact Factor NA I. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. aaf1098. A more complete list of genes associated with autoimmunity can be found in the review by Wang et al.138. Ultimately, during tumor progression, cancer cells show low immunogenicity and resistance to immune effector cells, thus expanding and escaping immune control. Clin. Manufacturing history of etanercept (Enbrel): consistency of product quality through major process revisions. & Lazar, G. A. Rev. Immunol. Investig. Rev. PubMed More studies are centered on understanding how to manipulate bacterial colonies, the discovery of therapeutic molecules, nutrient competitions, etc., that are required for successful application. Wochenschr. As we picked our May flowers, the editors picked their favorite cancer research studies published this month in the 10 AACR journals. Several factors have been involved in these advancements, and the most important ones include the development of thousands of different monoclonal antibodies that allow the identification of a large variety of cell subpopulations and the functional analysis of immune cells. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. L. B. Biol. Drug Discov. The 2017 IUIS phenotypic classification for primary immunodeficiencies. More recently, and with the increased knowledge of the human microbiome, the use of microorganisms in therapy has seen a resurgence. J. Immunol. Science 350, 981985 (2015). Phase I clinical trials have generally shown good tolerance to this therapy without serious adverse effects286. HIV AIDS 13, 446453 (2018). parasites and certain strains of Salmonella spp., Mycobacterium bovis and Mycobacterium tuberculosis129,130. Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers. Allergic diseases can be termed complex diseases that involve both genetic and environmental factors, and they influence not only the development of IgE-mediated sensitivity in the case of hypersensitivity type I allergies but also the subsequent development of clinical symptoms in a range of tissues, including skin, nose, and lung tissue162. 180, 8393 (1994). Specific memory within innate immune systems. Med. Rev. Low gut microbiota diversity in early infancy precedes asthma at school age. N. Engl. Immunologists, in cooperation with experts from other fields, have developed a variety of protocols and tools to achieve greater selectivity in the identification and analysis of human cell subsets, types of cytokines and receptors, chemokines, etc. U.S.A. 112, 80468051 (2015). & Jameson, J. M. Human and T cells in skin immunity and disease. Kuhlmann, A. S., Peterson, C. W. & Kiem, H. P. Chimeric antigen receptor T-cell approaches to HIV cure. It is crucial to find validated biomarkers (with predictive and/or prognostic value) that can help to stratify or select patients for the best immunotherapy. J. Immunol. Later, induced or adaptive regulatory T cells were also identified, including different subsets that carry several phenotypic markers and express various cytokine secretion profiles292. Paul Langerhans identified dendritic cells in human skin in 1868274, but these cells were not named until 1973 by Dr. Ralph M. Steinman (Nobel Prize in 2011) and Dr. Zanvil A. Cohn, who chose the term because the cell morphology, with long extensions, resembles that of neuronal dendrites275. 20, 46424655 (2014). Tanoue, T., Umesaki, Y. Quintin, J. et al. Researchers are developing safer and more powerful adjuvants. The idea that only jawed vertebrates developed immunological memory has also been challenged by the observation of resistance to reinfection in organisms that lack an adaptive immune response, such as plants86 and invertebrates87,88. Extensive research has focused on deciphering the role of ILCs to ensure the maintenance of tissue homeostasis and immune protection11,18. Type I IFNs (including IFN- and IFN-) exhibit several molecular actions that may be very relevant for use in therapy for a range of pathologies (such as autoimmune diseases and cancers)253. Med. 38, 129143 (2018). Lim, H. W., Hillsamer, P. & Kim, C. H. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th celldriven B cell responses. Rev. Association of human Fc gamma RIIa (CD32) polymorphism with susceptibility to and severity of meningococcal disease. Thus, vaccines are used for cases of allergies, cancers and autoimmune diseases. Abt, M. C. et al. Article The key of immunosurveillance is cancerous cell expression of tumor antigens that can activate various immune cell phenotypes; for simplicity, any overexpressed, mutated, dysregulated, or rearranged gene product expressed by a cancerous cell may be considered a tumor antigen. Researchers are working on vaccines that confer protection against all serotypes of a specific pathogen (universal). Immunol. Cho, J. H., Collins, J. J. Definition according to profiles of lymphokine activities and secreted proteins. 35, 585599 (2015). J. Exp. Cell 161, 264276 (2015). Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. Altmann, D. M. A Nobel Prize-worthy pursuit: cancer immunology and harnessing immunity to tumour neoantigens. Allergy vaccines are currently the only effective therapy that can stop the progression of the illness because treatment with anti-inflammatory drugs, such as anti-histaminic drugs or corticoids, mitigates the symptoms of the allergic processes but does not modify the natural course of the disease202,203. 34, 317334 (2016). You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research.
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