The active ingredients in the Hemochromatosis HelpTurmericCream are from a family of nutrient substances calledTetrahydrocurcuminoids, which are extracts ofturmeric/curcumin. The conclusion that piperine/black pepper raises turmeric absorption by 2000% sure gets the attention and has been quoted by numerous papers and online articles. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. Prog.Neurobiol. Several studies evaluating turmerics effectiveness (curcumin) in iron overload have shown reductions in ALT and AST liver enzymes, along with a marker called NTBI (Non-Transferrin Bound Iron). and Privacy Policy and steps will be taken to remove posts identified The active ingredients in the Hemochromatosis Help Turmeric Cream are from a family of nutrient substances called Tetrahydrocurcuminoids, which are extracts of turmeric/curcumin. Has anyone used the turmeric cream and if so, did it bring down the iron and the saturation? Toxicology 1-22-1996;107(1):39-45.https://pubmed.ncbi.nlm.nih.gov/8597030/, Mandel, S., Amit, T., Bar-Am, O., and Youdim, M. B. . Published research and numerous articles online have repeated this 2000% statistic over and over to the point where it is essentially accepted that black-pepper-derived piperine is beneficial for people taking turmeric. The glucuronidation pathway detoxifies numerous hormones, nutrients, bile acids, toxins, and medications, exemplifying just how important this process is for our health. These studies looking at turmeric and piperine are not using food; they use the extracted, concentrated chemical constituent derived from black pepper. It is a standardized extract prepared from the dried fruits of Piper nigrum (black pepper) and contains a minimum of 95% Piperine. Iron stored inside of cells causes oxidative damage leading to so many of the symptoms and problems in people with hemochromatosis. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. The challenge is how to get the turmeric into the cells of your body. Estimates place turmerics absorption at about 5% so you are not likely absorbing much from diet alone. at some point because we are trying to reeducate our cell brains to do so!! Hegge AB1, Schller RB, Kristensen S, Tnnesen HH. Hemochromatosis Help Turmeric Cream and Capsules According to the FDA, turmeric is generally regarded as safe. Pharmazie. Both options provide excellent, safe choices for those with iron overload! https://www.ncbi.nlm.nih.gov/pubmed/14517767, Piyachaturawat P, Glinsukon T, Toskulkao C. Acute and subacute toxicity of piperine in mice, rats and hamsters. In other words, while we want to enhance turmeric absorption, we dont want to do this at the expense of liver detoxification function, enhanced iron absorption, and other potential long-term effects. PMID: 3080587. https://pubmed.ncbi.nlm.nih.gov/3080587/, Unchern S, Saito H, Nishiyama N. Death of Cerebellar Granule Neurons Induced by Piperine Is Distinct from that Induced by Low Potassium. In general, turmeric and its active constituent, curcumin, have been shown to be an excellent anti-inflammatory supplement. It is possible that 1020 M curcumin is more than enough to chelate all iron and that the remaining iron-free curcumin induces autophagy, enhancing neoplastic transformation44,47. But the main answer is yes, it takes the load off of your liver. After a certain amount of time, does it just kind of die and become waste? So, in addition to lowering ferritin levels, how does turmeric support liver health? https://patient.info/forums/discuss/hemochromatosis-and-turmeric-570847. NTBI is also known as free iron and is the most likely form of iron to cause oxidative stress. Until I was diagnosed with HH My storage has gone to my liver causing cirrhosis, my storgae was 94% and levels 1975. Food Chem.Toxicol 1994;32(3):279-283.https://pubmed.ncbi.nlm.nih.gov/8157223/, Reddy, A. C. and Lokesh, B. R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Hemochromatosis Demystified Online Course, why you shouldnt use black pepper with turmeric, https://pubmed.ncbi.nlm.nih.gov/17897073/, https://pubmed.ncbi.nlm.nih.gov/16545682/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615657/, https://pubmed.ncbi.nlm.nih.gov/18651292/, https://pubmed.ncbi.nlm.nih.gov/17116705/, https://pubmed.ncbi.nlm.nih.gov/15345806/, https://pubmed.ncbi.nlm.nih.gov/15796163/, https://pubmed.ncbi.nlm.nih.gov/15084330/, https://pubmed.ncbi.nlm.nih.gov/17659826/, https://pubmed.ncbi.nlm.nih.gov/19100339/, https://pubmed.ncbi.nlm.nih.gov/21235521/, https://pubmed.ncbi.nlm.nih.gov/19534681/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509542/, https://pubmed.ncbi.nlm.nih.gov/29806132/, https://pubmed.ncbi.nlm.nih.gov/19594223/, https://pubmed.ncbi.nlm.nih.gov/17569207/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792534/, https://pubmed.ncbi.nlm.nih.gov/23281076/, https://pubmed.ncbi.nlm.nih.gov/21120596/, https://www.sciencedirect.com/science/article/abs/pii/S0300908415001777, Hemochromatosis Help Turmeric Supplements, Using Nutritional Supplements in Hemochromatosis, Supplements Created for the Hemochromatosis Patient, Benefits of Resveratrol in Hemochromatosis, Benefits of Milk Thistle in Hemochromatosis. The authors of the original study in 1998 knew of this mechanism of action. Teichmann A1, Heuschkel S, Jacobi U, Presse G, Neubert RH, Sterry W, Lademann J. In conclusion, the researchers from this study declared: Curcumin is a biologically active iron chelator. High glutathione, less oxidation, and lower iron are precisely what we want when facing iron overload! Curcumin, the active ingredient in turmeric, tends to be poorly absorbed by our digestive system. Hemochromatosis may be identified because of irregular blood test results after testing is done for . Researchers from this study concluded that curcumin is a biologically active iron chelator," exceptional news for people with hemochromatosis and iron overload! Unlike many commercially available curcumin formulas, the bioavailability, safety, and efficacy of BCM-95 curcumin has been demonstrated in numerous preclinical and human studies. If you re-read the quote at the beginning of this article, they state, piperine, a known inhibitor of hepatic and intestinal glucuronidation.. Hemochromatosis Helps Turmeric Capsules provides the patented BCM-95 brand of turmeric, a special form of turmeric with enhanced methods of absorption. Black tea. Renowned for centuries with a rich, historical use in plant and herbal medicine, turmeric has long been held in high regard for its beneficial effects. When I found a remedy that is generally considered safe that also possesses so many beneficial properties, you can see why Im so excited by the turmeric benefit to our health! Sign-up today for in-depth and empowering articles with actionable tips to assist you on your journey with hemochromatosis! Amazon.co.uk: Turmeric Cream A significant improvement in serum iron (could be correlated to the immediate release of iron from BioIron into systemic circulation); total iron binding capacity and serum ferritin level was also observed. Once turmeric grabs hold of and binds to an iron molecule, the turmeric then helps the body excrete the iron from your body. I think in most people there is a small amount of that, but for those of us with HH, it has potential to be much worse. Hemochromatosis Help I will also discuss the one major challenge to using turmeric medicinally and give you solutions so you can learn how to use this incredible herbal medicine correctly to make sure you receive its full benefits! Professional Quality Supplements Hand-Picked by the Naturopathic Doctors at Hemochromatosis Help. It's a very mild off-white/yellow-colored cream, as opposed to the vibrant orange-yellow from turmeric root or powder. An extract from Black pepper known as piperine is a very common addition to turmeric supplements. A topical cream of turmeric gets absorbed directly into the body, bypassing the gut to ensure maximal results. Required fields are marked *. Heres how to get some, Primary Hemochromatosis Autosomal Dominant, Hemochromatosis Help Turmeric Cream Reviews, Reversible Complications Of Hemochromatosis, Can You Take Zinc If You Have Hemochromatosis. Iron dysregulation in Alzheimers disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. 2009 Jan;41(1):40-59.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/, Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Turmeric Benefit for Hemochromatosis | Hemochromatosis Help 2009;14(2):300-308.https://pubmed.ncbi.nlm.nih.gov/19100339/, Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. Our unique topical cream of turmeric gets absorbed directly into the body, bypassing the gut to ensure maximal results. r/Hemochromatosis - Turmeric cream and HH any help in bringing down Hemochromatosis can be difficult to diagnose. Ordinary turmeric powders, pills, or teas, are only going to be used by your body a tiny amount. However, a deeper look at the situation just doesnt hold up. (I'm asking because I am also C282Y Homozygous, diagnosed over ten. Oral absorption of curcumin is generally poor due to its low solubility and instability in the intestinal environment. 2009;60 Suppl 1:43-55.https://pubmed.ncbi.nlm.nih.gov/18651292/, Tuntipopipat, S., Judprasong, K., Zeder, C., Wasantwisut, E., Winichagoon, P., Charoenkiatkul, S., Hurrell, R., and Walczyk, T. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal. unrestricted non-commercial use, distribution, and reproduction in. PMID: 23620848; PMCID: PMC3634921. What factors inhibit the absorption of iron? Additionally, a very common ingredient frequently added to turmeric supplements may be a poor choice for a person with hemochromatosis. XXXIII. Melon-flavored ice cream returns to Howell. 2008 Jul-Aug;70(4):445-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792534/, BioPerine, Sabinsa, https://bioperine.com, Black Pepper, Examine.com, https://examine.com/supplements/black-pepper/, Daware MB, Mujumdar AM, Ghaskadbi S. Reproductive Toxicity of Piperine in Swiss Albino Mice. It absorbs quickly, just like a lotion. Thats the opposite of what we want in hemochromatosis and iron overload. 2023 My Hemochromatosis Help. The BCM-95 demonstrated an over 6-fold increase in turmeric absorption compared to the piperine version! If you weigh 130 pounds, drink 65 to 130 ounces of water a day. Turmeric literally grabs hold of the iron thats inside the cells and brings it out. We have written extensively about the benefits of turmeric for hemochromatosis and how there is a large body of research demonstrating a ferritin and iron lowering effect of this herbal remedy. 16 Sterling Street, Asheville, North Carolina. But to also reduce the storage of too much iron?!? Hemochromatosis is a genetic disorder in which excess iron gets accumulated in the body. Scan this QR code to download the app now. Cookie Notice A really boring and strict diet. In addition to turmerics ferritin and transferrin saturation lowering abilities, this herbal remedy has been shown by researchers to have many additional potential benefits to a person with iron overload. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. 2014 Jan;46(1):2-18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/, Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. In Vivo 2005;19(1):119-123.https://pubmed.ncbi.nlm.nih.gov/15796163/, Bernabe-Pineda, M., Ramirez-Silva, M. T., Romero-Romo, M. A., Gonzalez-Vergara, E., and Rojas-Hernandez, A. Spectrophotometric and electrochemical determination of the formation constants of the complexes Curcumin-Fe(III)-water and Curcumin-Fe(II)-water. 2019 . I am 64-year old female who walks and/or bikes daily and have found out about this condition quite by accident as I am not having any issues and might just be one of the asymptomatic ones but it still could be doing damage to major organs. When oxidative damage occurs, a potential consequence is that liver enzymes such as ALT and AST leak into the bloodstream. If turmeric is beneficial for iron overload and piperine enhances the absorption of turmeric, well, sign me up! (Lovely). In addition to superior absorption, a topical skin application is easy and convenient to use. BCM-95CG thus, has potential for widespread application for various chronic diseases. $95.90 USD. After all of this has been said and done, piperine isnt even the best way to absorb turmeric! Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. I have a high count, near 5000 and after two months it dropped by 1000. Anyone else? I used wheatgrass which has some valid clinical documentation. Spectrochim.Acta A Mol.Biomol.Spectrosc. Biofactors. Specifically, oxidative stress is one of the most impactful problems of hemochromatosis and is a primary reason liver cells become less healthy. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis.https://en.wikipedia.org wiki DeferoxamineDeferoxamine Wikipedia, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Once turmeric grabs hold of and chelates iron molecules, the turmeric then helps the body to excrete the iron. Use Two Types of Turmeric for the Best Golden Chicken. Erratum in: Altern Med Rev. You should not stop taking any medication without first consulting your physician. Specifically, the names for the turmeric/curcumin ingredients in our product are: Tetrahydrodiferuloylmethane Tetrahydrodemethoxydiferuloylmethane Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The unexpected observation that cells treated with curcumin exhibited a decrease in ferritin raised the possibility that the chelator activity of curcumin might be sufficient to induce systemic iron depletion. (Reference). Out of all the natural remedies for iron overload, turmeric stands in first place in its ability to actually reduce iron overload. Many people with the disease don't have any symptoms other than high levels of iron in their blood. It's a very mild off-white/yellow-colored cream, as opposed to the vibrant orange-yellow from turmeric root or powder. Would you like to learn more ways to help your hemochromatosis? ment of hemochromatosis, dietary modifications that lower iron intake. Oral absorption of curcumin is generally poor due to its low solubility and instability in the intestinal environment. Effective Doses Studies typically use doses of 5002,000 mg of turmeric per day, often in the form of an extract with a curcumin concentration that is much higher than the amounts naturally occurring in foods. In mice, the iron went down in blood tests, but was being pushed into the organs. Out of all the natural remedies for iron overload, turmeric stands in first place in its ability to actually reduce iron overload. high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision. A community for the iron-overloaded. I only drink water with lemon, green tea with ginger and chamomile tea with honey. Natures best anti-inflammatory herb may also be a powerful holistic remedy for hemochromatos, All Educational Products (Books, Quick Tips, and Courses). Altern Med Rev. Ordinary turmeric powders, pills, or teas, are only going to be used by your body a very small amount. If you have any questions or comments, please dont hesitate to contact us.
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